Double Dose for More Intensive Support

At 600 mg per capsule, this formula delivers twice the benfotiamine of the standard dose. Research on benfotiamine in neuropathy and glycation defense used doses in the 300–600 mg range; this version provides the higher end of studied therapeutic doses.

Greater Transketolase Activation

Benfotiamine activates transketolase -the enzyme that diverts toxic glycolysis intermediates away from nerve and vascular damage pathways. A higher dose drives greater transketolase saturation, providing a stronger glycation-defense effect at the cellular level.

Defends Nerves Against Glycation

Chronic elevated glucose glycates proteins and nerves, producing AGEs (advanced glycation end-products) that cause lasting damage. Benfotiamine's transketolase mechanism is one of the few nutritional approaches that directly addresses AGE formation at its source.

5× More Bioavailable Than Standard Thiamine

Fat-soluble benfotiamine crosses cell membranes passively, reaching nerve and vascular tissues at concentrations that water-soluble thiamine HCL cannot achieve. This is why dose-for-dose, benfotiamine outperforms every water-soluble B1 form.

Supports Peripheral Circulation

Beyond nerve cells, benfotiamine supports the small blood vessels that supply peripheral tissues. By reducing vascular glycation and supporting healthy endothelial function, it helps maintain circulation to hands, feet, and extremities.

Replenishes Thiamine Depleted by Elevated Glucose

Persistently elevated blood sugar accelerates thiamine excretion via the kidneys. At the higher 600 mg dose, benfotiamine more aggressively rebuilds the thiamine deficit that metabolic stress creates -an important consideration for long-term nerve protection.