Vitamin B2 (Riboflavin)
Vitamin B2 (Riboflavin)
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- Item Form
- Capsule
- Primary Supplement Type
- Vitamin B2 (Riboflavin)
- Flavor
- Unflavored
- Product Benefits
- Migraine Prevention, Cellular Energy, Antioxidant Support
- Diet Type
- Gluten Free, Vegan, Non-GMO
- Supplement Formulation
- Individual Supplement
- Best Taken
- With food, once daily
- Manufactured In
- USA, GMP-certified facility
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before use, especially if you are pregnant, nursing, taking medications, or have a medical condition.
High-dose Riboflavin (Vitamin B2) 400 mg -the dose used in the landmark Schoenen RCT that cut migraine frequency nearly in half, plus full-spectrum cellular energy support.
Why It Works
Why 400 mg Riboflavin Is the Evidence-Backed Migraine Dose
Clinically Studied for Migraine Prevention
In a double-blind RCT (Schoenen et al., 1998), 400 mg/day riboflavin reduced migraine frequency by 50% in 59% of participants over three months. This dose is now included in multiple neurological society guidelines as a first-line preventive option.
Restores Mitochondrial Energy in Neurons
Riboflavin is a direct precursor to FAD and FMN -the two coenzymes that drive the mitochondrial electron transport chain. Research suggests migraineurs have impaired mitochondrial energy metabolism in brain tissue; high-dose B2 helps restore that efficiency.
Powers Every Cell in the Body
As the core of FAD and FMN, riboflavin is required for the metabolism of carbohydrates, fats, and proteins into ATP. Without it, cellular energy production slows across every organ system.
Supports Glutathione Recycling
Riboflavin is essential for glutathione reductase, the enzyme that regenerates your body's master antioxidant. This helps protect cells from the oxidative stress that accumulates during metabolic stress and inflammation.
Skin, Eye, and Tissue Integrity
Riboflavin supports the turnover and repair of rapidly dividing cells, including those lining the skin, eyes, and mucous membranes. Adequate levels help maintain healthy, resilient tissue throughout the body.
Nervous System Balance
B2 contributes to the conversion of B6 and folate into their active forms -nutrients that are themselves critical for neurotransmitter synthesis and nerve health. It functions as an upstream enabler of the entire B-vitamin network.
Migraine Frequency Reduction
Real RCT Data -Not Marketing Claims
The Schoenen 1998 double-blind, randomized, placebo-controlled trial is the foundational study for high-dose riboflavin in migraine prevention. Participants taking 400 mg/day saw migraine frequency cut by half after three months. Lower doses did not produce the same result, which is why the standard recommendation is 400 mg -exactly the dose in this bottle.
15%
22%
50%
Reduction in migraine attack frequency after 3 months
*Responder rate (≥50% reduction in attack frequency). Schoenen J, et al. (1998). Placebo group also showed improvement consistent with natural regression to mean.
Your Journey
What to Expect Over 3 Months
Foundation
Month 1
In the first two to four weeks, some people notice improved energy levels and reduced eye fatigue. Migraine prevention effects typically require a full loading period -most participants in the Schoenen trial did not see significant frequency reduction until weeks 8–12.
Note: your urine will turn a bright, fluorescent yellow within hours of taking riboflavin. This is harmless -it is simply the excess water-soluble vitamin being excreted and is a reliable sign the supplement is being absorbed.
Better Together
Combines Well With
Stack with these for a complete protocol, formulated to work synergistically.
Got Questions?
Frequently Asked Questions
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