Vitamin B2 (Riboflavin)
Vitamin B2 (Riboflavin)
★Recommended cadence, based on dosage & bottle size
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- Item Form
- Capsule
- Primary Supplement Type
- Vitamin B2 (Riboflavin)
- Flavor
- Unflavored
- Product Benefits
- Neurological Comfort, Cellular Energy, Antioxidant Support
- Diet Type
- Gluten Free, Vegan, Non-GMO
- Supplement Formulation
- Individual Supplement
- Best Taken
- With food, once daily
- Manufactured In
- USA, GMP-certified facility
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before use, especially if you are pregnant, nursing, taking medications, or have a medical condition.
What customers say
4.8 / 5 · 5 reviewsGreat vitamin
Works well. Causes urine to be bright yellow, but can tell it working.Great quality
Scott Rowan · July 2026
Works great
Works great as vitamin B supplement
Sen L · July 2026
Very good quality
Good quality
Robert C · July 2026
Riboflavin
Value for money, no side effects. Easy to swallow
Amazon Customer · March 2026
High-dose Riboflavin (Vitamin B2) 400 mg -the dose used in the landmark Schoenen RCT that supported neurological comfort in the majority of participants, plus full-spectrum cellular energy support.
Why It Works
Why 400 mg Riboflavin Is the Evidence-Backed Neurological Comfort Dose
Clinically Studied for Neurological Comfort Support
In a double-blind RCT (Schoenen et al., 1998), 400 mg/day riboflavin supported neurological comfort in 59% of participants over three months, with a 50% improvement in the responder group. This dose is now referenced in multiple neurological society guidelines.
Restores Mitochondrial Energy in Neurons
Riboflavin is a direct precursor to FAD and FMN -the two coenzymes that drive the mitochondrial electron transport chain. Research suggests individuals with suboptimal mitochondrial energy metabolism in brain tissue may benefit from high-dose B2 to help restore that efficiency.
Powers Every Cell in the Body
As the core of FAD and FMN, riboflavin is required for the metabolism of carbohydrates, fats, and proteins into ATP. Without it, cellular energy production slows across every organ system.
Supports Glutathione Recycling
Riboflavin is essential for glutathione reductase, the enzyme that regenerates your body's master antioxidant. This helps protect cells from the oxidative stress that accumulates during metabolic stress and inflammation.
Skin, Eye, and Tissue Integrity
Riboflavin supports the turnover and repair of rapidly dividing cells, including those lining the skin, eyes, and mucous membranes. Adequate levels help maintain healthy, resilient tissue throughout the body.
Nervous System Balance
B2 contributes to the conversion of B6 and folate into their active forms -nutrients that are themselves critical for neurotransmitter synthesis and nerve health. It functions as an upstream enabler of the entire B-vitamin network.
Neurological Comfort Support
Real RCT Data -Not Marketing Claims
The Schoenen 1998 double-blind, randomized, placebo-controlled trial is the foundational study for high-dose riboflavin and neurological comfort support. Participants taking 400 mg/day achieved a 50% improvement in the responder group after three months. Lower doses did not produce the same result, which is why the standard recommendation is 400 mg -exactly the dose in this bottle.
15%
22%
50%
Neurological comfort responder rate after 3 months
*Responder rate (≥50% improvement). Schoenen J, et al. (1998). Placebo group also showed improvement consistent with natural regression to mean.
Your Journey
What to Expect Over 3 Months
Foundation
Month 1
In the first two to four weeks, some people notice improved energy levels and reduced eye fatigue. Neurological comfort support typically requires a full loading period -most participants in the Schoenen trial did not see significant improvement until weeks 8–12.
Note: your urine will turn a bright, fluorescent yellow within hours of taking riboflavin. This is harmless -it is simply the excess water-soluble vitamin being excreted and is a reliable sign the supplement is being absorbed.
Better Together
Combines Well With
Stack with these for a complete protocol, formulated to work synergistically.
Got Questions?
Frequently Asked Questions
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